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Codeine is a prescription medication classified as an opioid analgesic , commonly used to relieve mild to moderate pain and cough . It works by changing how the brain and nervous system respond to pain signals. Often combined with other medications like acetaminophen (paracetamol) or ibuprofen , codeine enhances pain relief and is widely used in both acute and chronic care settings.

Codeine is an opioid analgesic (painkiller) and antitussive (cough suppressant). It is commonly used to treat mild to moderate pain, suppress coughs, and control diarrhea. Codeine is often combined with other medications, such as acetaminophen (Tylenol with codeine) or ibuprofen, for enhanced pain relief.

Although less potent than morphine, codeine can still cause dependence, addiction, and respiratory depression, especially at high doses or with prolonged use.

Mild to moderate pain relief – Used for pain relief after surgery, injuries, or dental procedures.
Combination with other pain relievers – Often mixed with acetaminophen or ibuprofen to improve pain relief. Relieves severe cough – Often found in prescription cough syrups to relieve persistent, dry coughs.

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Slows bowel movements – Helps treat severe diarrhea by decreasing bowel activity. Migraine and tension headache relief – Sometimes used for headaches that don’t respond to standard pain relievers.
Cold and flu symptom management – Used in some cold medications to reduce cough and discomfort. Binds to opioid receptors – Blocks pain signals in the brain and nervous system.
Suppresses the cough reflex – Affects the medulla (brainstem) to reduce coughing.
Slows gastrointestinal activity – Helps reduce diarrhea by slowing the rate of bowel movements.

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Like all opioids, codeine can cause side effects such as:

• Drowsiness or dizziness

• Nausea and vomiting

• Constipation

• Dry mouth

• Lightheadedness

Serious risks include respiratory depression , especially at high doses or when combined with other central nervous system depressants like alcohol or sedatives.

Prescription-only medications in most countries.
Controlled substance due to potential for abuse.
Restricted over-the-counter sales – In some countries, low-dose codeine cough syrups and pain relievers are available, but are strictly regulated.

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